General Information

  • ID:  hor007129
  • Uniprot ID:  Q14116??38-193)
  • Protein name:  Interleukin-18
  • Gene name:  IFNL2; IL28A, ZCYTO20;
  • Organism:  Homo sapiens
  • Family:  IL-1 family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  GO:0005829 cytosol; GO:0005576 extracellular region; GO:0005615 extracellular space
  • GO BP:  GO:0005125 cytokine activity; GO:0045515 interleukin-18 receptor binding
  • GO CC:  GO:0030101 natural killer cell activation; GO:0042088 T-helper 1 type immune response; GO:0120162 positive regulation of cold-induced thermogenesis; GO:0032722 positive regulation of chemokine production; GO:0042092 type 2 immune response; GO:0042104 positive regulation of activated T cell proliferation; GO:0042119 neutrophil activation; GO:0030431 sleep; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein; GO:2000556 positive regulation of T-helper 1 cell cytokine production; GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction; GO:0051142 positive regulation of NK T cell proliferation; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0150078 positive regulation of neuroinflammatory response; GO:0032819 positive regulation of natural killer cell proliferation; GO:0010744 positive regulation of macrophage derived foam cell differentiation; GO:

Sequence Information

  • Sequence:  FGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
  • Length:  156
  • Propeptide:  MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA